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Natural products (NPs) have long been valued as a rich source of pharmaceutical agents, nutritional supplements, cosmetic ingredients , etc., and are known to be life-essential for their originating species. With the rapid advance in analytical techniques, there is a clear shift from ‘detection’ to ‘quantification’ in current NP studies, which result in a large number of the quantified contents of NPs. These quantified data are valuable, since the content of a specific NP is largely responsible for (a) determining the yield and cost for producing the corresponding pharmaceutical/nutritional/cosmetic products and (b) understanding the molecular mechanisms underlying the species-species cooperation/competition and species resistance to different stresses.
However, significant variation in NP’s content is frequently observed, which may seriously affect the ‘Return On Investment’ of NP-based industry and also result in severe vulnerability of ecological systems. Therefore, many studies have been conducted to identify the mechanisms underlying the variation in NP’s content. These mechanisms include: molecular regulation, species interaction, environmental factor, and the combined one. Since the variation and mechanism data are essential for inspiring the future NP-related ‘quantification’ research, here, NPcVar is established for providing such valuable data.