Details of Natural Product (NP)

General Information of Natural Product (ID: NP0889)
  Natural Product Name
Daidzein
  Synonyms
daidzein; 486-66-8; 4',7-Dihydroxyisoflavone; Daidzeol; 7,4'-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-; 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; MFCD00016954; 4,7-Dihydroxyisoflavone; UNII-6287WC5J2L; CHEMBL8145; 4',7-Dihydroxy-iso-flavone; d-(+)-alpha-methylbenzylamine; CHEBI:28197; 6287WC5J2L; Daidzein,(S); 7-Hydroxy-3-(4-hydroxy-phenyl)-chromone; DSSTox_CID_2310; 7-Hydroxy-3-(4-hydroxy-phenyl)-chromen-4-one; DSSTox_RID_76543; DSSTox_GSID_22310; CAS-486-66-8; SMR000326832; Daidzein (6CI); CCRIS 7600; K 251b; SR-01000075492; EINECS 207-635-4; BRN 0231523; NPI 031E; Spectrum_000255; Tocris-1417; BiomolKI_000060; Spectrum2_000053; Spectrum3_000191; Spectrum4_001964; Spectrum5_000857; Lopac-D-7802; BiomolKI2_000066; UPCMLD-DP052; 4',7-dihydroxy isoflavone; 7-HYDROXY-3-(4-HYDROXYPHENYL)CHROMONE; 4',7-dihydroxy-Isoflavone; 4',7-Dihydroxyisoflavanone; Lopac0_000412; Oprea1_182317; Oprea1_305345; SCHEMBL19814; BSPBio_001741; Daidzein, analytical standard; KBioGR_002432; KBioSS_000735; SPECTRUM200789; 5-18-04-00089 (Beilstein Handbook Reference); MLS000859973; MLS001304056; MLS006011853; BIDD:ER0120; DivK1c_001023; SPBio_000205; Daidzein, >=98%, synthetic; BMK1-F12; GTPL2828; MEGxm0_000123; NPI-031E; d-(+)-alpha-methylbenzyl amine; DTXSID9022310; UPCMLD-DP052:001; ACon0_001477; ACon1_000543; BDBM23420; HMS503M07; K-251b; KBio1_001023; KBio2_000735; KBio2_003303; KBio2_005871; KBio3_001241; AOB5524; 4',7-Dihydroxyisoflavone, 97%; NINDS_001023; 7,4'-Dihydroxy-isoflavone (3a); HMS1922P18; HMS2233H24; HMS3261C06; HMS3267J04; HMS3370C03; HMS3412O12; HMS3468L18; HMS3649B20; HMS3655A18; HMS3676O12; ALBB-015933; AMY25222; BCP28286; HY-N0019; Tox21_201444; Tox21_303650; Tox21_500412; BBL010490; CCG-38357; LMPK12050038; s1849; STK801626; ZINC18847034; Daidzein (4',7-Dihydroxyisoflavone); 7-hydroxy-3-(4-hydroxyphenyl)-4H-; AKOS002385052; Isoflavone, 4',7-dihydroxy- (8CI); AC-6035; ACN-034764; Daidzein, purum, >=98.0% (TLC); DB13182; KS-5260; LP00412; MCULE-8239511422; SDCCGMLS-0066422.P001; SDCCGSBI-0050397.P003; IDI1_001023; SMP1_000089; NCGC00015365-01; NCGC00015365-02; NCGC00015365-03; NCGC00015365-04; NCGC00015365-05; NCGC00015365-06; NCGC00015365-07; NCGC00015365-08; NCGC00015365-09; NCGC00015365-10; NCGC00015365-11; NCGC00015365-12; NCGC00015365-13; NCGC00015365-14; NCGC00015365-15; NCGC00015365-16; NCGC00015365-17; NCGC00015365-18; NCGC00015365-31; NCGC00025156-01; NCGC00025156-02; NCGC00025156-03; NCGC00025156-04; NCGC00025156-05; NCGC00025156-06; NCGC00025156-07; NCGC00025156-08; NCGC00025156-09; NCGC00025156-10; NCGC00168978-01; NCGC00168978-02; NCGC00257367-01; NCGC00258995-01; NCGC00261097-01; SY049259; 7-Hydroxy-3-(4-hydroxy?phenyl)?chromone; BB 0259520; D2668; EU-0100412; FT-0603419; FT-0665448; FT-0665449; N1862; SW218107-2; 7-hydroxy-3-(4-hydroxyphenyl)-chromen-4-one; D 7802; S00273; US8552057, 7; AB00052712-08; AB00052712_10; 486D668; Daidzein, primary pharmaceutical reference standard; Q408732; Q-200924; SR-01000075492-1; SR-01000075492-3; SR-01000075492-7; SR-01000075492-8; BRD-K42095107-001-02-3; BRD-K42095107-001-05-6; BRD-K42095107-001-08-0; SR-01000075492-12; 80E3ED75-D852-4D97-9BD6-B5ADE7EA25A1; 7-Hydroxy-3-(4-hydroxy-phenyl)-4H-1-benzo-pyran-4-one; 7-Hydroxy-3-(4-hydroxy?phenyl)-4H-1-benzo?pyran-4-one; UNII-71B37NR06D component ZQSIJRDFPHDXIC-UHFFFAOYSA-N; Daidzein, United States Pharmacopeia (USP) Reference Standard; Daidzein, Pharmaceutical Secondary Standard; Certified Reference Material; ZF1
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  Formula C15H10O4
  Weight 254.24
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
  InChI Key ZQSIJRDFPHDXIC-UHFFFAOYSA-N
  Isomeric SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
  Canonical SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
  External Links PubChem ID 5281708
CAS ID 486-66-8
NPASS ID NPC234560
HIT ID C1278
CHEMBL ID CHEMBL8145
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Lentil var. Tina
  Factor Name: H2O2 Treatment; Mannitol Treatment; NaCl Treatment; High Temperature Treatment; Low Temperature Treatment [1]
              Species Info Factor Info
               Experiment Detail
Seeds were sterilized in 1% (v/v) sodium hypochloride (Sigma-Aldrich, USA) for 10 min, then drained and washed with distilled water until they reached neutral pH. They were placed in distilled water and soaked for 6 h at 25 ℃ . Seeds were dark germinated for 8 days in a growth chamber (SANYO MLR-350H) on Petri dishes (125 mm) lined with absorbent paper. Seedlings were watered with 5 ml of Milli-Q water daily. Sprout (8-day-old) samples were gently collected, weighed (fresh mass), rapidly frozen and kept in polyethylene bags at -20 ℃ . For each treatment, three replicates were performed.Elicitation conditions were selected in previous screening studies. For the experiments, temperature (4 ℃ and 40 ℃ - TC and TH, respectively), H2O2 (20 mM and 200 mM - Ox1 and Ox2, respectively), mannitol (200 mM and 600 mM - Os1 and Os2, respectively) and NaCl (100 mM and 300 mM - S-Os1 and S-Os2, respectively) were selected as abiotic elicitors. All solutions were freshly prepared before each application. Mannitol (Os1, Os2), NaCl (S-O1, S-O2) and H2O2 (Ox1) treatments were applied by watering daily (not soaking) 2-day-old sprouts with 5 ml of test solution. For Ox2 (200 mM H2O2) treatment 2-day-old seedlings were only once watered with 5 ml of 200 mM H2O2 and then cultivated under standard conditions. For temperature conditioning treatment, 2-day-old sprouts were incubated at 4 ℃ and 40 ℃ (TC and TH, respectively) for 1 h and then cultivated under standard conditions. Sprout (8-day-old) samples were gently collected, weighed (fresh mass), rapidly frozen and kept in polyethylene bags at -20 ℃ .
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               Factor Function
Application of abiotic elicitors (environmental shocks) was an effective method for improvement of sprout pro-health potential via an increase of phenolic contents and subsequent elevation of antioxidant potential. Innovative application of elicitors on 2-day-old sprouts (not seed) allowed the elimination of the unfavorable influence of the factors employed on germination yield and biomass production. Assuming that the optimal germination conditions are those which most effectively increase the antioxidant potential without any negative influence on biomass accumulation and nutritional quality the elicitation with 20 mM H2O2 for the future applications is recommended.
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               Factor Part Location NP Content
 
Normal condition
 Sprouts NA
NP Content: 0.00017 ± 0.00001 mg/g flour
 
Induction with 20 mM H2O2
 Sprouts NA
NP Content: 0.00027 ± 0.00001 mg/g flour
 
Induction with 200 mM H2O2
 Sprouts NA
NP Content: 0.00072 ± 0.00012 mg/g flour
 
Induction with 200 mM mannitol
 Sprouts NA
NP Content: 0.00156 ± 0.00014 mg/g flour
 
Induction with 600 mM mannitol
 Sprouts NA
NP Content: 0.00106 ± 0.00012 mg/g flour
 
Induction with 100 mM NaCl
 Sprouts NA
NP Content: 0.00014 ± 0 mg/g flour
 
Induction with 300 mM NaCl
 Sprouts NA
NP Content: 0.0001 ± 0.00001 mg/g flour
 
Induction at 4 ℃
Sprouts NA
NP Content: 0.00012 ± 0.00001 mg/g flour
 
Induction at 40 ℃
 Sprouts NA
NP Content: 0.00039 ± 0.00002 mg/g flour
References
1 Elicitation with abiotic stresses improves pro-health constituents, antioxidant potential and nutritional quality of lentil sprouts