Details of Natural Product (NP)

General Information of Natural Product (ID: NP1420)
  Natural Product Name
Vincristine
  Synonyms
vincristine; 22-Oxovincaleukoblastine; Vinkristin; Leurocristine; 57-22-7; Vincrystine; leucristine; vincristin; Vincristina [DCIT]; Vincristinum [INN-Latin]; CHEBI:28445; NSC-67574; Kyocristine; Vincaleukoblastine, 22-oxo-; VIN; NCGC00163700-01; Vincrstine; Leurocristine sulfate; DSSTox_CID_12278; DSSTox_RID_78909; DSSTox_GSID_32278; Tecnocris; CAS-57-22-7; Tecnocris (TN); LCR; VCR; Vincristine (INN); Vincasar (1:1 sulfate salt); C46H56N4O10; Oncotcs; Oncovin (1:1 sulfate salt); rel-Vincristine; Vincrex (1:1 sulfate salt); (+)-Vincristine; oncovin (brand name); 22-oxo-vincaleukoblastine; SCHEMBL3709; CHEMBL90555; GTPL6785; DTXSID1032278; HMS2090E19; Tox21_112067; BDBM50139772; ZINC85432549; Lilly 37231 (1:1 sulfate salt); Tox21_112067_1; NCGC00163700-02; NCGC00163700-04; NCGC00263543-01; NCI60_026703; SRI-10749-04; SRI-10749-05; N2252; X1247; C07204; D08679; 866V483; Q408977; Vincaleukoblastine, 22-oxo- 22-Oxovincaleukoblastine; 1217704-92-1; methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
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  Formula C46H56N4O10
  Weight 825
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
  InChI Key OGWKCGZFUXNPDA-XQKSVPLYSA-N
  Isomeric SMILES CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
  Canonical SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
  External Links PubChem ID 5978
CAS ID 57-22-7
NPASS ID NPC260909
HIT ID C1149
CHEMBL ID CHEMBL90555
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Eutypella sp. CrP14
  Factor Name: PDB medium [1]
              Species Info Factor Info
               Experiment Detail
The fungus used in this study was isolated from stem cuttings of C. roseus plant collected from the nursery of the Indian Institute of Science, Bangalore, India. The endophytic fungus was grown on PDA plates for about 10 days. Three 5 mm agar plugs containing mycelium of Eutypella spp were transferred to 400 ml of potato dextrose broth, in a 1 L conical flask and incubated at 25 ℃ under stationary condition for 21 days.
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               Factor Part Location NP Content
 
PDB medium (25℃ + 21 days)
 Stems Bangalore, India
NP Content: 53 ± 5.0 µg/l
References
1 Fungal vincristine from Eutypella spp - CrP14 isolated from Catharanthus roseus induces apoptosis in human squamous carcinoma cell line -A431