Details of Natural Product (NP)

General Information of Natural Product (ID: NP1452)
  Natural Product Name
Vincamine
  Synonyms
vincamine; 1617-90-9; Pervincamine; Devincan; Angiopac; Minorine; Vincamidol; Novicet; Arteriovinca; Equipur; Monorin; (+)-Vincamine; Methyl vincaminate; Anasclerol; Oxygeron; Vincafor; Perval; Vincimax; Vincasaunier; Decincan; Devinkan; Tripervan; Vincadar; Vincafolina; Vincagil; Vincamin; Vincapront; Vinkametrin; UNII-996XVD0JHT; Minorin; Pervone; Vincachron; Vincapan; Vinodrel retard; Ocu-vinc; Vinca-Ecobi; Vinca-Minor; Anasclerol (base); 14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester; 996XVD0JHT; CHEBI:9985; MFCD00078054; Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16alpha)-; DSSTox_CID_20134; DSSTox_RID_79448; DSSTox_GSID_40134; Vraap; Vincamina [DCIT]; Vincaminum; Vincamina; Alkaloid obtained from Vinca minor; Vincaminum [INN-Latin]; methyl 14beta-hydroxy-14,15-dihydro-3alpha,16alpha-eburnamenine-14alpha-carboxylate; Vincamine [INN:BAN:DCF]; HSDB 7150; EINECS 216-576-3; NSC 91998; Oxybral; Cetal retard; NSC-91998; (3?,14?,16?)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester; Vincamine (FP); NCGC00094824-01; Vincamine (INN); Prestwick_495; CAS-1617-90-9; Cetal retard (TN); Vincamine, 98%; Prestwick0_000271; Prestwick1_000271; Prestwick2_000271; Prestwick3_000271; Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16.); BSPBio_000142; GTPL349; MLS002154249; SCHEMBL147179; SPBio_002361; BPBio1_000158; CHEMBL1165342; DTXSID9040134; BCBcMAP01_000080; HMS1568H04; HMS2095H04; HMS2268C20; HMS3712H04; AMY39091; BCP05837; HY-B1021; ZINC1069082; Tox21_111342; Tox21_301968; s3891; AKOS015896471; Tox21_111342_1; CCG-208544; CS-4536; DB13374; KS-5179; methyl (3alpha,14beta,16alpha)-14-hydroxy-14,15-dihydroeburnamenine-14-carboxylate; SMP1_000314; Vincamine, analytical reference material; NCGC00184983-01; NCGC00184983-03; NCGC00255542-01; AC-22625; SMR000112509; C09251; D08677; J10447; 617V909; A851579; Q416225; Q-100193; BRD-K40902647-001-03-7; Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methylester, (3a,14b,16a)-; (3alpha,14beta,16alpha)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acidmethyl ester; Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-,methyl ester, (3alpha,14beta,16alpha)-; methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.0?,?.0?,??.0??,??]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate; methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.0^{2,7}.0^{8,18}.0^{15,19}]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate; methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate; Methyl (41S,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
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  Formula C21H26N2O3
  Weight 354.4
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1
  InChI Key RXPRRQLKFXBCSJ-GIVPXCGWSA-N
  Isomeric SMILES CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4[C@](C2)(C(=O)OC)O
  Canonical SMILES CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O
  External Links PubChem ID 15376
CAS ID 1617-90-9
NPASS ID NPC289299
CHEMBL ID CHEMBL1165342
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Geomyces sp. strain CH1
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
Healthy samples (stems and roots) of Nerium indicum were collected from Heng Mountain, Hunan province, China, and immediately packed and sent back to our laboratory within 24 h. The endophytic fungi initially were cultured on PDA plates at 27 ℃ for 3 days. Then, the endophytic fungi were inoculated in 250 mL Erlenmeyer flasks with 100 mL fermentation medium containing under a constant temperature incubator shaker (ZHWY-2102C; Shanghai Zhicheng Analytical Co., Ltd, China) in order to produce secondary metabolites. The fungi were grown at 27 ℃ at 170 rpm for 3 days and then incubated under still conditions for 4 days.
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               Factor Part Location NP Content
 
PDA medium (27℃ +7 days)
 Stems Hunan, China
NP Content: 1.279 mg/L
References
1 Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum, Apocynaceae