Details of Natural Product (NP)

General Information of Natural Product (ID: NP1478)
  Natural Product Name
9-Methoxycamptothecin
  Synonyms
9-Methoxycamptothecin; 39026-92-1; Camptothecin, 9-methoxy-; NSC176323; C21H18N2O5; NSC-176323; (S)-4-ethyl-4-hydroxy-10-methoxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione; NSC 176323; CAMPTOTHECIN,9-METHOXY; CHEMBL522112; SCHEMBL1004508; DTXSID00192292; HY-N6011; ZINC5011446; 8044AH; MFCD03840473; ZB1864; AKOS037514539; NCGC00385478-01; NCI60_001450; CS-0032150; N2593; F17695; (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (S)-4-ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; {1H-Pyrano[3',} {4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-,} 4-ethyl-4-hydroxy-10-methoxy-, (S)-; 1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-, 4-ethyl-4-hydroxy-10-methoxy-, (S)-; NCGC00385478-01_C21H18N2O5_1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-
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  Formula C21H18N2O5
  Weight 378.4
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C21H18N2O5/c1-3-21(26)14-8-16-18-11(7-12-15(22-18)5-4-6-17(12)27-2)9-23(16)19(24)13(14)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1
  InChI Key XVMZDZFTCKLZTF-NRFANRHFSA-N
  Isomeric SMILES CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O
  Canonical SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O
  External Links PubChem ID 123617
CAS ID 39026-92-1
NPASS ID NPC128115
CHEMBL ID CHEMBL522112
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Fusarium solani culture-collection MTCC:9667
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
The endophytic fungal strains were isolated from trees of the species A. dimidiata E. Mey. ex Arn (Icacinaceae) growing in the Western Ghats region, a mega-bio-diversity hot spot in India. The location coordinates of Periya, the collection locality are 11° 50′ 0″ North, 75° 50′ 0″ East. For each pure isolate, single hyphal tips were incubated in 250 ml conical flasks containing 50 ml of pre-sterilized PDA broth. Flasks were agitated at 200 rpm on a rotary shaker at 28℃ for 4 days.
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               Factor Part Location NP Content
 
PDA medium (28℃ + 4 days)
 Leaves; Stem bark Ghats, India
NP Content: 38.3 µg/100 g
      Species Name: Fusarium solani culture-collection MTCC:9668
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
The endophytic fungal strains were isolated from trees of the species A. dimidiata E. Mey. ex Arn (Icacinaceae) growing in the Western Ghats region, a mega-bio-diversity hot spot in India. The location coordinates of Periya, the collection locality are 11° 50′ 0″ North, 75° 50′ 0″ East. For each pure isolate, single hyphal tips were incubated in 250 ml conical flasks containing 50 ml of pre-sterilized PDA broth. Flasks were agitated at 200 rpm on a rotary shaker at 28℃ for 4 days.
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               Factor Part Location NP Content
 
PDA medium (28℃ + 4 days)
 Leaves; Stem bark Ghats, India
NP Content: 44.9 µg/100 g
References
1 Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin