Details of Natural Product (NP)

General Information of Natural Product (ID: NP1479)
  Natural Product Name
10-Hydroxycamptothecin
  Synonyms
10-Hydroxycamptothecin; 19685-09-7; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; 10-hydroxycamptothecine; 10-Hydroxy camptothecin; Hydroxycamptothecine; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin, hydroxy-; 10-Hydroxy-Camptothecin; 10-HCPT; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; UNII-9Z01632KRV; NSC107124; CHEMBL273862; CHEBI:81395; 9Z01632KRV; Hydroxy camptothecine; MFCD02093100; NSC-107124; (+)-(S)-10-HYDROXYCAMPTOTHECIN; (S)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione; C20H16N2O5; Camptothecin, 10-hydroxy-; Camptothecine, 10-hydroxy-; (20S)-4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; NSC 107124; 10-Hydroxycamptochecin; (S)-10-Hydroxycamptothecin hydrate; (20S)-10-Hydroxycamptothecin; CAMPTOTHECIN, 10-HYDROXY; 10-Hydroxy-CPT; Spectrum_001639; SpecPlus_000763; Spectrum2_001660; Spectrum3_001621; Spectrum4_001815; Spectrum5_000549; ethyl(dihydroxy)[?]dione; SCHEMBL25875; BSPBio_003281; Irinotecan related compound a; KBioGR_002454; KBioSS_002119; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, hydrate, (S)-; DivK1c_006859; SPECTRUM1504123; SPBio_001819; KBio1_001803; KBio2_002119; KBio2_004687; KBio2_007255; KBio3_002501; DTXSID00941444; EX-A988; AOB33756; BCP01385; HY-N0095; ZINC3979155; Camptothecine, 10-hydroxy- (8CI); 2136AH; BDBM50008922; CCG-38770; s2423; s3898; AKOS015919293; AC-5502; ACN-035239; BCP9000058; CS-5193; DB12385; NCGC00095986-01; NCGC00095986-02; NCGC00095986-03; NCGC00095986-04; NCGC00178165-01; AC-13221; AS-13196; H577; NCI60_000173; SY010687; H1463; N2591; 85H097; A25382; C17939; SR-05000002620; Q-100241; SR-05000002620-1; BRD-K63784565-001-02-1; BRD-K63784565-001-03-9; Q27155328; 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (alphaS)-alpha,2-Dihydroxy-alpha-ethyl-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinoline-7-acetic acid 7,8-lactone; (S)-10-Hydroxycamptothecin;-;(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3 inverted exclamation mark ,4 inverted exclamation mark :6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ((S)-10-Hydroxycamptothecin); (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)- (9CI); 1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)-; 4-Ethyl-4,10-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin)
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  Formula C20H16N2O5
  Weight 364.4
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
  InChI Key HAWSQZCWOQZXHI-FQEVSTJZSA-N
  Isomeric SMILES CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
  Canonical SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
  External Links PubChem ID 97226
CAS ID 19685-09-7
NPASS ID NPC151781
CHEMBL ID CHEMBL273862
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Fusarium solani culture-collection MTCC:9668
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
The endophytic fungal strains were isolated from trees of the species A. dimidiata E. Mey. ex Arn (Icacinaceae) growing in the Western Ghats region, a mega-bio-diversity hot spot in India. The location coordinates of Periya, the collection locality are 11° 50′ 0″ North, 75° 50′ 0″ East. For each pure isolate, single hyphal tips were incubated in 250 ml conical flasks containing 50 ml of pre-sterilized PDA broth. Flasks were agitated at 200 rpm on a rotary shaker at 28℃ for 4 days.
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               Factor Part Location NP Content
 
PDA medium (28℃ + 4 days)
 Leaves; Stem bark Ghats, India
NP Content: 8.2 µg/100 g
References
1 Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin