Details of Natural Product (NP)

General Information of Natural Product (ID: NP1522)
  Natural Product Name
Maculosin
  Synonyms
Maculosin; Cyclo(L-pro-L-tyr); 4549-02-4; (3s,8as)-3-(4-hydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; CYCLO-(L-TYROSINE-L-PROLINE) INHIBITOR; Cyclo(-Pro-Tyr); (3S,8aS)-3-[(4-hydroxyphenyl)methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; CHEBI:6631; (3S,8AR)-3-(4-HYDROXYBENZYL)HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE; (3S,8aS)-Hexahydro-3-[(4-hydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione; cyclo(pro-tyr); 1w1y; Cyclo(L-Pro-L-Tyr-); Cyclo-(L-Pro-L-Tyr); Cyclo(L-prolinyl-L-tyrosine); CHEMBL359788; SCHEMBL12035399; DTXSID30196526; ZINC1629943; MFCD03093467; DB04520; TYP; Q27089361; Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-((4-hydroxyphenyl)methyl)-, (3S,8aS)-; Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-((4-hydroxyphenyl)methyl)-, (3S-trans)-
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  Formula C14H16N2O3
  Weight 260.29
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C14H16N2O3/c17-10-5-3-9(4-6-10)8-11-14(19)16-7-1-2-12(16)13(18)15-11/h3-6,11-12,17H,1-2,7-8H2,(H,15,18)/t11-,12-/m0/s1
  InChI Key LSGOTAXPWMCUCK-RYUDHWBXSA-N
  Isomeric SMILES C1C[C@H]2C(=O)N[C@H](C(=O)N2C1)CC3=CC=C(C=C3)O
  Canonical SMILES C1CC2C(=O)NC(C(=O)N2C1)CC3=CC=C(C=C3)O
  External Links PubChem ID 119404
CAS ID 4549-02-04
NPASS ID NPC242159
CHEMBL ID CHEMBL359788
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Aeromicrobium sp. strain LGMB491
  Factor Name: SG medium [1]
              Species Info Factor Info
               Experiment Detail
V. divergens leaves with no marks or injuries were collected from 21 plants located in the Pantanal sul-mato-grossense/Brazil, specifically in two regions of the Pantanal of Miranda, Abobral (19° 30′ 09.5″ S, 57° 02′ 32.2″ W) and Sao Bento (19° 28′ 53.9″ S, 57° 02′ 36.9″ W). A large-scale fermentation (10 L) of strain LGMB491 was performed using SG culture medium at 36 ℃ for 10 days.
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               Factor Part Location NP Content
 
SG medium (36℃ + 10 days)
 Leaves Pantanal, Brazil
NP Content: 10.8 mg
References
1 Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil)