Details of Natural Product (NP) | NPcVar

General Information of Natural Product (ID: NP1632)
Natural Product Name		Chloramphenicol
Synonyms		chloramphenicol; 56-75-7; Chloromycetin; Chlornitromycin; Levomycetin; Halomycetin; Levomicetina; Chlorocid; Globenicol; Chloroamphenicol; Alficetyn; Chloramex; Chlorocol; Detreomycin; Oleomycetin; Fenicol; Amphenicol; Aquamycetin; Chloramficin; Chloramfilin; Cloramicol; D-Chloramphenicol; Enteromycetin; Juvamycetin; Leukomycin; Sificetina; Chloronitrin; Ciplamycetin; Detreomycine; Dextromycetin; Intramycetin; Laevomycetinum; Levomitsetin; Mediamycetine; Micochlorine; Novophenicol; Stanomycetin; Amphicol; Amseclor; Anacetin; Austracil; Austracol; Biocetin; Biophenicol; Chemicetin; Chemicetina; Chlomycol; Chloramsaar; Chlorasol; Chloricol; Chlorocaps; Chlorocide; Chloroptic; Chlorovules; Cidocetine; Cloramficin; Cloramidina; Clorocyn; Cloromisan; Clorosintex; Comycetin; Cylphenicol; Doctamicina; Econochlor; Embacetin; Erbaplast; Farmicetina; Hortfenicol; Isicetin; Ismicetina; Isophenicol; Kemicetina; Kemicetine; Leukomyan; Loromisin; Mastiphen; Medichol; Micloretin; Micoclorina; Microcetina; Novomycetin; Ophthochlor; Rivomycin; Ambofen; Catilan; Chlomin; Desphen; Emetren; Enicol; Ertilen; Glorous; Kamaver; Klorita; Mychel; Isopto fenicol; Chlora-tabs; Chlorocidin C; Chloramphenicolum; Chloroject L; Normimycin V; Chlorocid S; Klorocid S; Mychel-Vet; Chloramfenikol; Cloramfenicol; Novochlorocap; Sintomicetina; Synthomycetin; Chloromax; Oftalent; Otachron; Pantovernil; Pentamycetin; Quemicetina; Romphenil; Ronphenil; Septicol; Chloro-25 vetag; Mycinol; Opclor; Otophen; Paraxin; Sintomicetine R; Sno-Phenicol; Chlorocidin C tetran; Cloroamfenicolo; D-(-)-Chloramphenicol; Chloromycetny; Synthomycetine; Treomicetina; Tevcocin; Tifomycine; Unimycetin; Veticol; Viceton; Tiromycetin; Leukamycin; Loromisan; Tifomycin; D-(-)-threo-Chloramphenicol; Tega-Cetin; 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide; I 337A; U-6062; NCI-C55709; NSC 3069; D-threo-Chloramphenicol; 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; D(-)-threo-Chloramphenicol; D-(-)-threo-1-p-Nitrophenyl-2-dichloroacetylamino-1,3-propanediol; CAF; Cloramfen; Ak-chlor; UNII-66974FR9Q1; CHEBI:17698; NSC3069; D-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide; D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol; Chloramphenicol (Chloromycetin); Chlorofair; Cloramfenicolo; Syntomycin; Optomycin; D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol; D-(-)-threo-1-(4-Nitrophenyl)-2-dichloroacetamido-1,3-propanediol; D-threo-(1R,2R)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol; NSC-3069; Chloramphenicol-[ring-3,5-3H]; MFCD00078159; Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R,R))-; Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R,R)]-; 66974FR9Q1; NCGC00091011-05; CAF (pharmaceutical); 125440-98-4; DSSTox_CID_265; Chloramfenikol [Czech]; Chloromycetny [Polish]; Cloramfenicolo [DCIT]; D-threo-N-(1,1'-Dihydroxy-1-p-nitrophenylisopropyl)dichloroacetamide; CAM; 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide; Chlorbiotic (Veterinary); Cloroamfenicolo [Italian]; DSSTox_RID_75473; Chloramphenicol crystalline; DSSTox_GSID_20265; Elase-Chloromycetin; Gloveticol; Mycochlorin; Ocuphenicol; Sintomicetin; Tyfomycine; Chlorocin; Halcetin; Levocin; Levoplast; Levosin; Levovetin; Myclocin; Soluthor; Chloramphenicol, d-; Chloroptic S.O.P.; Cloramfenicol [INN-Spanish]; Chloramphenicolum [INN-Latin]; Ophtochlor; Synthomycine; Tevcosin; Opelor; D(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol; D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; (-)-chloramphenicol; Econochlor (TN); Amphicol (TN); Ophthocort (Salt/Mix); SMR000471851; Chloromyxin (Salt/Mix); Chloromycetin (TN); CCRIS 3922; HSDB 3027; SR-01000761450; EINECS 200-287-4; Elase-Chloromycetin (Salt/Mix); BRN 2225532; chioramphenicol; Chloramphenicole; AI3-25003; Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-; CAS-56-75-7; NCGC00094620-01; Thiamphenicol,(S); 2787-09-9; ACETAMIDE, 2,2-DICHLORO-N-[(1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-NITROPHENYL)ETHYL]-; D-(-)-threo-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl))-p-nitrophenethylacetamide; D-(-)-threo-2,2-Dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)]-p-nitrophenethylacetamide; Chloramphenicol [USP:INN:BAN:JAN]; Chloramphenicol,(S); Prestwick3_000031; CHEMBL130; Epitope ID:114066; 9-hydroxy-9-phenylxanthene; SCHEMBL16111; BSPBio_000121; WLN: WNR DYQY1QMVYGG; 4-13-00-02742 (Beilstein Handbook Reference); MLS001055372; MLS001066397; MLS001332385; MLS001332386; MLS002222155; BIDD:GT0145; DivK1c_000544; BPBio1_000135; D-(-)-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol; D-(-)-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol; DTXSID7020265; BDBM23447; Chloramphenicol, gamma-irradiated; GTPL10901; HMS501L06; KBio1_000544; NINDS_000544; Chloramphenicol (JP17/USP/INN); HMS2090M15; HMS2095G03; HMS2269N06; HMS3712G03; ZINC113382; Chloramphenicol, >=98% (HPLC); Acetamide, 2,2-dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-; Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-; BCP12150; D-(-)-threo-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide; D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol; HY-B0239; RKL10087; Tox21_111306; Tox21_400061; s1677; AKOS005111001; CCG-220031; DB00446; MCULE-7778960570; D-threo-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide; IDI1_000544; SMP1_000065; NCGC00091011-01; NCGC00091011-02; NCGC00091011-03; NCGC00091011-04; NCGC00091011-06; NCGC00091011-08; NCGC00091011-09; NCGC00091011-20; Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (theta-(theta,theta))-; Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-; AS-14683; M163; NCI60_002620; Chloramphenicol, puriss., 98.0-102.0%; AB00374860; Chloramphenicol, tested according to Ph.Eur.; SW198497-2; C-3307; C00918; Chloramphenicol 100 microg/mL in Ethyl acetate; D00104; AB00374860-13; AB00374860-14; AB00374860_15; Chloramphenicol, meets USP testing specifications; Q274515; Chloramphenicol, VETRANAL(TM), analytical standard; SR-01000761450-2; SR-01000761450-3; SR-01000761450-5; BRD-K08111712-001-02-7; BRD-K08111712-001-16-7; Chloramphenicol, Antibiotic for Culture Media Use Only; Chloramphenicol, BioReagent, suitable for plant cell culture; Chloramphenicol, certified reference material, TraceCERT(R); Chloramphenicol, British Pharmacopoeia (BP) Reference Standard; Chloramphenicol, European Pharmacopoeia (EP) Reference Standard; Chloramphenicol, United States Pharmacopeia (USP) Reference Standard; D-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol; 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide; Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-; Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]; Chloramphenicol, Biotechnology Performance Certified, suitable for plant cell culture; D-(-)-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide; D-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-4-nitrophenethyl]acetamide; 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(hydroxy(oxido)amino)phenyl)ethyl)acetamide, (1R, 2R)-; Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R,R)-(+-)-; Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4- nitrophenyl)ethyl]-, [R-(R,R)]-; Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-; Acetamide,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-,D-(-)-threo-; Acetamide,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R,R)]-; Chloramphenicol 10 microg/mL in Acetonitrile. Short expiry date due to chemical nature of component(s); D-(-)-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-beta-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-alpha, alpha-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide Click to Show/Hide
Formula		C₁₁H₁₂Cl₂N₂O₅
Weight		323.13
Structure
Structure		3D Structure Download			2D Structure Download
InChI		InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI Key		WIIZWVCIJKGZOK-RKDXNWHRSA-N
Isomeric SMILES		C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
Canonical SMILES		C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
External Links		PubChem ID		5959
		CAS ID		56-75-7
		NPASS ID		NPC159589
		CHEMBL ID		CHEMBL130
NP Activity Charts		Click to show/hide
Activity Info

The Content Variation of Natural Product Induced by Different Factor(s)
*Species Name: Aspergillus clavatonanicus* strain MJ31**
					Factor Name: PDB medium																																																																[1]
Species Info Factor Info
Experiment Detail																						Healthy plant (Mirabilis jalapa L.) was collected from Dampa Tiger Reserve Forest [DTRF] (23° 44′ N 92° 39′ E), Mizoram, Northeast India during February, 2014. The cut ends were sealed with wax and were brought to the laboratory. Five mycelial agar plug of grown strain was inoculated in 2 L Erlenmeyer flasks containing 700 ml potato dextrose broth (PDB) media and incubated at 26 ℃ for three weeks. Click to Show/Hide
Mechanism																						Ketosynthase (KS) domain of polyketide synthases (PKS) type I and adenylation (A) domain of non-ribosomal peptide synthetases (NRPS) were detected in strain MJ31 which might play a role in antimicrobial activity. An expected 700 bp band of KS domain was detected by LC3 and LC5C primers which were responsible for the synthesis of partially reducing (PR) type PKSs. NRPS gene was also detected with the amplified product size of 300 bp. Click to Show/Hide
Factor																																								Part										Location																				NP Content
PDB medium (26℃ + 21 days)																																								Root tissues										Mizoram, India																				NP Content: 9.2 µg/g

References
1	Determination and production of antimicrobial compounds by Aspergillus clavatonanicus strain MJ31, an endophytic fungus from Mirabilis jalapa L. using UPLC-ESI-MS/MS and TD-GC-MS analysis

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