Details of Natural Product (NP)

General Information of Natural Product (ID: NP1941)
Natural Product Name	Cytochalasin F
Synonyms	Cytochalasin F; UNII-O75KLH41XO; 36084-18-1; O75KLH41XO; (1S,4E,6R,10R,12E,14S,15S,17R,18S,19S,20S)-20-benzyl-6-hydroxy-10,17,18-trimethyl-2,16-dioxa-21-azatetracyclo[12.8.0.01,19.015,17]docosa-4,12-diene-3,22-dione; Cytochalasin F6; SCHEMBL33570; MFCD01710738; ZINC105565553; Q27285430; 24-Oxa(14)cytochalasa-13,21-diene-1,23-dione, 6,7-epoxy-20-hydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)- Click to Show/Hide
Formula	C₂₉H₃₇NO₅
Weight	479.6
Structure
Structure	3D Structure Download		2D Structure Download
InChI	InChI=1S/C29H37NO5/c1-18-9-7-13-21(31)15-16-24(32)34-29-22(14-8-10-18)26-28(3,35-26)19(2)25(29)23(30-27(29)33)17-20-11-5-4-6-12-20/h4-6,8,11-12,14-16,18-19,21-23,25-26,31H,7,9-10,13,17H2,1-3H3,(H,30,33)/b14-8+,16-15+/t18-,19+,21-,22+,23+,25+,26+,28-,29-/m1/s1
InChI Key	CXWYFIYZAZBQGQ-QJMMVEIUSA-N
Isomeric SMILES	C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@H]4[C@](O4)([C@H]([C@H]2[C@@H](NC3=O)CC5=CC=CC=C5)C)C)O
Canonical SMILES	CC1CCCC(C=CC(=O)OC23C(C=CC1)C4C(O4)(C(C2C(NC3=O)CC5=CC=CC=C5)C)C)O
External Links	PubChem ID	21672263
	CAS ID	36084-18-1
	CHEMBL ID	CHEMBL4849943
NP Activity Charts	Click to show/hide
Activity Info

The Content Variation of Natural Product Induced by Different Factor(s)
Species Name: Pseudolagarobasidium acaciicola
	Factor Name: PDB medium				[1]
Species Info Factor Info
Experiment Detail		The fungus P. multirostrata EA-12 was isolated from fresh leaves of E. Adenophorum collected in Kunming Institute of Botany, Kunming, Yunnan province, PR China in July 2012. This fungal strain was cultured on potato dextrose agar medium at 25 ℃ for 10 days. The agar plugs were inoculated in 500-ml Erlenmeyer flasks, each containing 100 ml of potato dextrose media. Flask cultures were incubated at 28 ℃ on a rotary shaker at 160r.p.m. for 2 days as seed culture. Sixty 500-ml Erlenmeyer flasks each containing 150 ml of potato dextrose broth were individually inoculated with 25′l of seed culture and incubated at 25 ℃ on a rotary shaker at 160r.p.m. for 15 days. Click to Show/Hide
Factor			Part	Location		NP Content
PDB medium (25℃ + 15 days)			Fresh leaves	Kunming, Yunnan province, China		NP Content: 0.0031 g

References
1	Cytochalasins from cultures of endophytic fungus Phoma multirostrata EA-12