Details of Natural Product (NP)

General Information of Natural Product (ID: NP1979)
  Natural Product Name
Trichodermin
  Synonyms
Trichoderonin|Trichodermin|4682-50-2|UNII-WF22557W91|WG 696|WF22557W91|12,13-Epoxytrichothec-9-en-4-ol acetate|[(1S,2R,7R,9R,11R,12S)-1,2,5-trimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-11-yl] acetate|ND 8|NSC 73846|Trichothec-9-en-4-ol, 12,13-epoxy-, acetate|NSC 267033|NSC73846|NSC267033|CHEMBL4463552|Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4beta)-|DTXSID701017605|Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4.beta.)-|ZINC4214539|4beta-aceoxy-12,13-epoxytrichothec-9-ene|Q256431|Trichothec-9-en-4beta-ol, 12,13-epoxy-, acetate|[(2S)-trimethylspiro[[?]-2,2'-oxirane]yl] acetate
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  Formula C17H24O4
  Weight 292.4
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17+/m1/s1
  InChI Key HNEGCRMUYSKRRR-IKIFYQGPSA-N
  Isomeric SMILES CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H](C[C@H]([C@@]34CO4)O2)OC(=O)C)C)C
  Canonical SMILES CC1=CC2C(CC1)(C3(C(CC(C34CO4)O2)OC(=O)C)C)C
  External Links PubChem ID 20806
CAS ID 4682-50-2
CHEMBL ID CHEMBL4463552
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Trichoderma brevicompactum strain 0248
  Factor Name: Fermentation Medium [1]
              Species Info Factor Info
               Experiment Detail
The endophytic fungus 0248 was isolated from healthy garlic based on antifungal activity. Fresh mycelium were picked and inoculated into 500 mL Erlenmeyer flasks containing 100 mL PD medium. After 2 days of incubation at 28 ± 1 °C on a rotary shaker at 150 rpm, 3 mL culture liquid was transferred as seeds into a 300-mL Erlenmeyer flask containing 30 mL medium (20 gL 1 dextrose, 5 gL 1 peptone, 1 gL 1 beef extract, 0.001 gL 1 ZnSO47H2O and 0.01 gL 1 NH4Cl). The resulting culture was kept on a rotary shaker at 180 rpm for 4 days at 28 ± 1 °C.
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               Factor Part Location NP Content
 
Fermentation Medium (20 g/L dextrose, 5 g/L peptone, 1 g/L beef extract, 0.001 g/L ZnSO47H2O and 0.01 g/L NH4Cl) (28 ± 1 degrees Celsius + 4Days + 180 rpm)
 NA NA
NP Content: 258 mg
References
1 Antifungal activity of metabolites of the endophytic fungus Trichoderma brevicompactum from garlic