The producing microorganism, strain TP-A0456, was isolated from the wild plant of Cryptomeria japonica collected in Kosugi-machi, Toyama, Japan. Streptomyces sp. TP-A0456 cultured on a slant agar medium was inoculated into five 500-ml K-l flasks each containing 100 ml of the seed medium consisting of soluble starch 1%, glucose 0.5%, NZ-case (Humco Scheffield Chemical Co.) 0.3%, yeast extract (Difco Laboratories) 0.2%, tryptone (Difco Laboratories) 0.5%, K₂HPO₄ 0.1%, MgSO₄-7H₂O 0.05% and CaCO₃ 0.3% (pH 7.0). The inoculated flasks were cultivated on a rotary shaker (200 rpm) at 30℃ for 4days. Three-ml of the seed culture was transferred into a hundred 500-ml K-l flasks each containing 100 ml of the production mediumconsisting of glucose 0.5%, glycerol 2%, soluble starch 2%, Pharmamedia (Traders Protein) 1.5%, yeast extract (Difco Laboratories) 0.3% and Diaion HP-20 (Mitsubishi Chemical Co.) 1%. The pH of the medium was adjusted to 7.0 before sterilization. The inoculated flasks were cultured on a rotary shaker (200 rpm) at 30 ℃ for 6 days.