Details of Natural Product (NP)

General Information of Natural Product (ID: NP1382)
  Natural Product Name
Mellein
  Synonyms
Mellein; Ochracin; 17397-85-2; 3,4-Dihydro-8-hydroxy-3-methylisocoumarin; AO-2; 8-hydroxy-3-methylisochroman-1-one; (+/-)-MELLEIN; 8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one; 8-HYDROXY-3-METHYL-ISOCHROMAN-1-ONE; 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-methyl-; ISOCOUMARIN, 3,4-DIHYDRO-8-HYDROXY-3-METHYL-; 3,4-dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-1-one; CHEMBL226090; 1200-93-7; CHEBI:38760; 8-Hydroxy-3-methyl-3,4-dihydro-1H-isochromen-1-one; 3,4-Dihydro-8-hydroxy-3-methyl-(1H)-2-benzopyran-1-one; Antibiotic AO-2; Antibiotic BV-1; (R)-3,4-Dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-1-one; (R)-Mellein; BV-1; (R)-(-)-Mellein; (.+/-.)-Mellein; ALM-9; SCHEMBL1230955; SCHEMBL13925643; DTXSID60891794; BDBM50208249; AKOS006228659; 3-methyl-8-hydroxy-3,4-dihydroisocoumarin; Q6813065; 3-Methyl-8-hydroxy-3,4-dihydro-1H-2-benzopyran-1-one; 8-hydroxy-3-methyl-3,4-dihydro-1H-2-benzopyran-1-one; Isocoumarin, 3,4-dihydro-8-hydroxy-3-methyl, (.+/-.)-; 3,4-Dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-1-one, (.+/-.)-
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  Formula C10H10O3
  Weight 178.18
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C10H10O3/c1-6-5-7-3-2-4-8(11)9(7)10(12)13-6/h2-4,6,11H,5H2,1H3
  InChI Key KWILGNNWGSNMPA-UHFFFAOYSA-N
  Isomeric SMILES CC1CC2=C(C(=CC=C2)O)C(=O)O1
  Canonical SMILES CC1CC2=C(C(=CC=C2)O)C(=O)O1
  External Links PubChem ID 28516
CAS ID 17397-85-2
NPASS ID NPC470831
CHEMBL ID CHEMBL226090
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Aspergillus flocculosus strain CBS 112784
  Factor Name: Rice medium [1]
              Species Info Factor Info
               Experiment Detail
Fungal material: The endophytic fungus was isolated from the fresh stems of Markhamia platycalyx family (Bignoniaceae) collected in October 2010 from Al-Zohriya gardens (Al-Zamalek, Giza, Egypt). Small-scale fermentation: A small-scale fermentation was carried out in two Erlenmeyer flasks (1 L each) on rice medium, which was prepared with 100 g of rice powder and approximately 100 mL of demineralized water just enough to cover the rice layer. The rice media was autoclaved prior to fungal inoculation. A 15-day fungal inoculum grown on petri dish was inoculated on the sterile rice medium and was allowed to grow at room temperature under static condition for 30 days. Medium-scale 30-day rice culture fermentation: A medium scale fermentation was performed in 10 Erlenmeyer flasks (1 L each) on rice solid medium for 30 days under same condition applied to small scale culture.
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               Factor Part Location NP Content
 
Medium-scale fermentation: Rice medium (25℃ + 30 days)
 Fresh stems Al-Zamalek, Giza, Egypt
NP Content: 11 mg
      Species Name: Xylaria sp. G12
  Factor Name: PDB Medium [2]
              Species Info Factor Info
               Experiment Detail
The endophytic fungus Coniothyrium sp., internal strain No. zw86, was isolated from the plant Salsola oppostifolia, growing on Gomera, in the Canary Islands. It was cultivated on 12 l of 5% w/v biomalt solid agar medium at room temperature for 28 days.
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               Factor Part Location NP Content
 
PDB Medium (25 degrees Celsius + 21Days)
 branch Songkhla province, Thailand
NP Content: 1 mg
References
1 Isolation of anticancer and anti-trypanosome secondary metabolites from the endophytic fungus Aspergillus flocculus via bioactivity guided isolation and MS based metabolomics
2 Indanone and mellein derivatives from the Garcinia-derived fungus Xylaria sp. PSU-G12