Isolation of endophytic fungus: The fungus was isolated from the nut of Garcinia kola bought at Mokolo local market in Yaounde (Cameroon). Phomopsis sp. was cultured in 12 flat culture bottles containing 100 g rice and 100 mL water enriched with 0.3% peptone each, autoclaved at 121 ℃ for 45 min. Each flask received about 5 small pieces of mycelium from PDA plate under sterile conditions. After 40 days of growth at 25 ℃ , ethyl acetate (12 × 500 mL) was added to each bottle, homogenized and filtered after 24 h and taken to dryness to afford 11.6 g of crude extract.