Details of Natural Product (NP)

General Information of Natural Product (ID: NP1492)
  Natural Product Name
Chaetomugilin A
  Synonyms
chaetomugilin A; CHEBI:68805; 11-Epichaetomugilin A; CHEMBL494746; 1041640-66-7; Q27137189; (6aS,7aR,8R,9R,11aR,11bS)-5-chloro-7a-hydroxy-3-[(1E,3R,4R)-4-hydroxy-3-methylpent-1-en-1-yl]-6a,8,9-trimethyl-6a,7a,8,9,11a,11b-hexahydro-6H,11H-pyrano[3',4':4,5]furo[2,3-h]isochromene-6,11-dione
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  Formula C23H27ClO7
  Weight 450.9
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C23H27ClO7/c1-10(12(3)25)6-7-14-8-15-16(9-29-14)17-18-21(27)30-13(4)11(2)23(18,28)31-22(17,5)20(26)19(15)24/h6-13,17-18,25,28H,1-5H3/b7-6+/t10-,11-,12-,13-,17-,18+,22+,23-/m1/s1
  InChI Key LNHWUFUMZSBRBY-YELMBXGASA-N
  Isomeric SMILES C[C@@H]1[C@H](OC(=O)[C@H]2[C@@]1(O[C@]3([C@@H]2C4=COC(=CC4=C(C3=O)Cl)/C=C/[C@@H](C)[C@@H](C)O)C)O)C
  Canonical SMILES CC1C(OC(=O)C2C1(OC3(C2C4=COC(=CC4=C(C3=O)Cl)C=CC(C)C(C)O)C)O)C
  External Links PubChem ID 24857881
CAS ID 1041640-66-7
NPASS ID NPC31641
CHEMBL ID CHEMBL494746
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Chaetomium globosum
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
The fungal strain C. globosum was separated from the sterilized leaves of G. biloba, a medicinal plant growing in Linyi, Shandong province, China. The fungus C. globosum was cultivated on PDA medium for 5 days at 28 ℃ to provide the culture broth (30 L).
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               Factor Part Location NP Content
 
PDA medium (28℃ + 5 days)
 Leaves Linyi, Shandong province, China
NP Content: 2.7 mg
      Species Name: Chaetomium globosum TY-2
  Factor Name: Oatmeal Medium [2]
              Species Info Factor Info
               Experiment Detail
A strain of C. globosum TY-2 was initially isolated from the plant Polygonatum sibiricum, collected in 2015 from Linan, Zhejiang Province, China. Serial transfers of one of the resulting colonies from Polygonatum sibiricum provided a pure strain of C. globosum. The fungal strain was cultured at 28 &#8451 for six weeks in a oatmeal medium (50 L) containing 1 % soluble sucrose and 0.1 % casein.
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               Factor Part Location NP Content
 
Oatmeal Medium with 1 % soluble sucrose and 0.1 % casein (28 degrees Celsius + 42Days)
 NA Linan, Zhejiang Province, China
NP Content: 1.9 mg
References
1 Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
2 Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum