The fungal strain, Ascotricha sp., was isolated from the mud sample collected on the coastal beach in Fenghua County, Zhejiang Province, China. The fungus was cultivated in flask with shaking 180 rpm and at 28 ℃. The liquid medium was composed of D-mannitol of 20.0 g, D-glucose of 20.0 g, yeast extract of 5.0 g, peptone of 10.0 g, KH₂PO₄ of 0.5 g, MgSO₄ of 0.3 g, corn syrup of 1.0 g, and sea salt of 33 g, which were dissolved in distilled water of 1000 mL. After 7 days of cultivation, the fermented broth (65 L) was filtered through cheesecloth to be separated into the supernatant and the mycelia.