General Information of Natural Product (ID: NP1542)
  Natural Product Name
Proximicin B
  Synonyms
Proximicin B; CHEMBL562052; SCHEMBL16072063; 1029061-05-9
Click to Show/Hide
  Formula C20H19N3O7
  Weight 413.4
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C20H19N3O7/c1-28-20(27)23-14-9-17(30-11-14)19(26)22-13-8-16(29-10-13)18(25)21-7-6-12-2-4-15(24)5-3-12/h2-5,8-11,24H,6-7H2,1H3,(H,21,25)(H,22,26)(H,23,27)
  InChI Key BZMYFWODEQYLTK-UHFFFAOYSA-N
  Isomeric SMILES COC(=O)NC1=COC(=C1)C(=O)NC2=COC(=C2)C(=O)NCCC3=CC=C(C=C3)O
  Canonical SMILES COC(=O)NC1=COC(=C1)C(=O)NC2=COC(=C2)C(=O)NCCC3=CC=C(C=C3)O
  External Links PubChem ID 24829331
CAS ID 1029061-05-9
CHEMBL ID CHEMBL562052
  NP Activity Charts   Click to show/hide

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Verrucosispora strain MG-37
  Factor Name: Fermentation medium [1]
              Species Info Factor Info
               Experiment Detail
Strain MG-37 was isolated from sediment collected by us (ATB, GK) in the Raune Fjord, Norway (N 60° 15.898, E 5° 08.237) at a depth of 250 meters. Strain MG-37 was cultivated in a 10-liter stirred tank fermentor (Biostat S, B. Braun Melsungen, Germany) in a complex medium that consisted of soluble starch 10 g, glucose 10 g, glycerol 10 g, cornsteep powder (Marcor) 2.5 g, Bacto peptone 5.0 g, yeast extract (Ohly Kat) 2.0 g, NaCl 1.0 g and CaCO3 3.0 g in 1.0 liter tap water, adjusted to pH 7.3 prior to sterilization. The fermentor was inoculated with 5 vol-% of shake cultures, grown in 500-ml Erlenmeyer flasks with one baffle for 48 hours on a rotary shaker at 120 rpm and 27 ℃ using the same medium. The fermentation was carried out for 96 hours at 27 ℃ with an aeration rate of 0.5 liter/liter culture/minute and an agitation of 250 rpm.
Click to Show/Hide
               Factor Part Location NP Content
 
Fermentation medium containing soluble starch 10 g, glucose 10 g, glycerol 10 g, cornsteep powder 2.5 g, Bacto peptone 5.0 g, yeast extract 2.0 g, NaCl 1.0 g and CaCO3 3.0 g (27℃ + 4 days + PH7.3 + 250 rpm)
NA Raune Fjord, Norway
NP Content: 13 mg/L
References
1 Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora