Details of Natural Product (NP)

General Information of Natural Product (ID: NP1449)
Natural Product Name	Grandisin
Synonyms	Grandisin; C10622; 53250-50-3; AC1L9DK8; CHEBI:5535; DTXSID40967805; ZINC04098808; 3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)oxolane; Q27106797; (2S,3S,4S,5S)-3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran; 2alpha,5beta-Bis(3,4,5-trimethoxyphenyl)-3beta,4alpha-dimethyltetrahydrofuran Click to Show/Hide
Formula	C₂₄H₃₂O₇
Weight	432.5
Structure
Structure	3D Structure Download		2D Structure Download
InChI	InChI=1S/C24H32O7/c1-13-14(2)22(16-11-19(27-5)24(30-8)20(12-16)28-6)31-21(13)15-9-17(25-3)23(29-7)18(10-15)26-4/h9-14,21-22H,1-8H3/t13-,14-,21-,22-/m0/s1
InChI Key	ZPINJJOPURFFNV-WJWAULOUSA-N
Isomeric SMILES	C[C@H]1[C@@H]([C@H](O[C@@H]1C2=CC(=C(C(=C2)OC)OC)OC)C3=CC(=C(C(=C3)OC)OC)OC)C
Canonical SMILES	CC1C(C(OC1C2=CC(=C(C(=C2)OC)OC)OC)C3=CC(=C(C(=C3)OC)OC)OC)C
External Links	PubChem ID	442876
	CAS ID	53250-50-3
	HIT ID	C0708

The Content Variation of Natural Product Induced by Different Factor(s)
*Species Name: Phomopsis* sp. Strain VA-35**
	Factor Name: Czapek medium				[1]
Species Info Factor Info
Experiment Detail		A two-step culture was used for each fungus. Initially, the fungi were inoculated into 20 mL of Czapek medium, supplemented with 3% of sucrose and the cultures were incubated at 30 ℃ for 3 days, with shaking at 120 ℃ rpm. After cultivation the resulting mycelia were harvested by filtration and transferred to 20 mL of Czapek medium, containing 1% of sucrose and supplemented with a solution of grandisin in DMSO, resulting 0.4 mg/mL as final concentration in the media. The cultures were reincubated at the same conditions for 8 days. Click to Show/Hide
Factor			Part	Location		NP Content
Czapek medium with 3% of sucrose (30℃ + 3 days) + Czapek medium with 1% of sucrose (30℃ + 8 days)			NA	NA		NP Content: 60 mg

References
1	Biotransformation of a Tetrahydrofuran Lignan by the Endophytic Fungus Phomopsis sp.