Details of Natural Product (NP)

General Information of Natural Product (ID: NP1481)
  Natural Product Name
Altenusin
  Synonyms
Altenusin; Alutenusin; 31186-12-6; 2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid; UNII-WM31322YA1; MLS000877038; WM31322YA1; [1,1'-Biphenyl]-2-carboxylicacid, 3,4',5'-trihydroxy-5-methoxy-2'-methyl-; SMR000440664; 2-(4,5-dihydroxy-2-methyl-phenyl)-6-hydroxy-4-methoxy-benzoic acid; MS 341; MLS004257367; CHEMBL483531; MEGxm0_000134; Altenusin, >=98% (HPLC); SCHEMBL16224897; ACon0_001034; ACon1_000227; BDBM50576; cid_6918469; CHEBI:141340; HMS2267A11; ZINC13118241; MCULE-1285768547; HY-121153; CS-0079551; BRD-K99407061-001-01-8; Q27292712; 4-methoxy-2-[2-methyl-4,5-bis(oxidanyl)phenyl]-6-oxidanyl-benzoic acid; (1,1'-Biphenyl)-2-carboxylic acid, 2,4',5'-trihydroxy-5-methoxy-2'-methyl-; [1,1'-Biphenyl]-2-carboxylic acid, 3,4',5'-trihydroxy-5-methoxy-2'-methyl-; 2,4',5'-Trihydroxy-5-methoxy-2'-methyl-(1,1'-biphenyl)-2-carboxylic acid; 3,4',5'-Trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid; NCGC00180762-02!2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid; 1402-75-1
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  Formula C15H14O6
  Weight 290.27
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)
  InChI Key ADPBTBPPIIKLEH-UHFFFAOYSA-N
  Isomeric SMILES CC1=CC(=C(C=C1C2=C(C(=CC(=C2)OC)O)C(=O)O)O)O
  Canonical SMILES CC1=CC(=C(C=C1C2=C(C(=CC(=C2)OC)O)C(=O)O)O)O
  External Links PubChem ID 6918469
CAS ID 31186-12-6
NPASS ID NPC138978
CHEMBL ID CHEMBL483531
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Alternaria alternata isolate Tche153
  Factor Name: YES medium [1]
              Species Info Factor Info
               Experiment Detail
Apparently healthy leaves of T. chebula (Family Combretaceae) were collected from Suanluang Rama IX Public Park, Bangkok, Thailand. The endophytic fungus A. alternata Tche-153 was cultivated on PDA agar plates at 25 ℃ for 7 days. Six pieces (@ 0.5 × 0.5 cm) of mycelial agar plugs were inoculated into a 1000-ml Erlenmeyer flask containing 200 ml of yeast extract sucrose (YES) broth and incubated at 25 ℃ under still conditions for 21 days.
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               Factor Part Location NP Content
 
YES medium (25℃ + 21 days)
 Leaves Bangkok, Thailand
NP Content: 10 mg
      Species Name: Botryosphaeria dothidea strain KJ-1
  Factor Name: Rice Medium [2]
              Species Info Factor Info
               Experiment Detail
The endophytic fungal strain KJ-1 was isolated from the symptomless tissue of stem bark of M. azedarach L., which was collected at Yangling, Shaanxi province, China, in August 2011. The producing strain was cultured on a plate of potato dextrose agar (PDA) medium at 28 ± 0.5 °C for 5 days. Then one piece (approximately 7 mm2) of mycelium was inoculated aseptically to 50 mL Erlenmeyer flasks each containing 20 mL of PD liquid medium, and the seed liquids were incubated at 28 ± 0.5 °C for 3 days on a rotary shaker at 120 rpm. A suspension (100 µL) of the seed liquid was inoculated aseptically to 500 mL Erlenmeyer flasks each containing 60 g of rice and 90 mL of distilled water. There were 300 flasks in total, and the flask cultures were incubated at 28 ± 0.5 °C for 4 weeks.
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               Factor Part Location NP Content
 
Rice Medium (28 ± 0.5 degrees Celsius + 28Days)
 tissue of stem bark Yangling, Shaanxi province, China
NP Content: 38 mg
References
1 Azole-synergistic Anti-Candidal Activity of Altenusin, a Biphenyl Metabolite of the Endophytic Fungus Alternaria alternata Isolated from Terminalia chebula Retz.
2 Secondary metabolites from the endophytic Botryosphaeria dothidea of Melia azedarach and their antifungal, antibacterial, antioxidant, and cytotoxic activities