Details of Natural Product (NP)

General Information of Natural Product (ID: NP1493)
  Natural Product Name
Chaetoglobosin A
  Synonyms
Chaetoglobosin A; Chaetoglobosins; 50335-03-0; (1R,3E,6R,7E,9S,11E,13R,14S,16R,17S,18R,19S)-6-hydroxy-19-(1H-indol-3-ylmethyl)-7,9,16,17-tetramethyl-15-oxa-20-azatetracyclo[11.8.0.01,18.014,16]henicosa-3,7,11-triene-2,5,21-trione; MLS000876953; NSC 366739; BRN 1097707; SMR000440607; SCHEMBL33582; CHEMBL472850; MEGxm0_000025; ACon0_000301; ACon1_002056; OUMWCYMRLMEZJH-VOXRAUTJSA-; DTXSID20891790; REGID_for_CID_6438437; HY-N6744; LMPK11000003; ZINC100064774; MCULE-3611836443; (13)Cytochalasa-13,17,21-triene-1,20,23-trione, 6,7-epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl-, (7S,13E,16S,17E,19R,21E)-; CS-0092508; Q15410885
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  Formula C32H36N2O5
  Weight 528.6
  Structure Could Not Find 2D Structure
3D Structure Download 2D Structure Download
  InChI InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7+,13-12+,18-14+/t17-,19-,22-,24-,27-,28+,29-,31+,32+/m0/s1
  InChI Key OUMWCYMRLMEZJH-VOXRAUTJSA-N
  Isomeric SMILES C[C@H]\\1C/C=C/[C@H]2[C@H]3[C@](O3)([C@H]([C@@H]4[C@@]2(C(=O)/C=C/C(=O)[C@@H](/C(=C1)/C)O)C(=O)N[C@H]4CC5=CNC6=CC=CC=C65)C)C
  Canonical SMILES CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
  External Links PubChem ID 6438437
CAS ID 50335-03-0
NPASS ID NPC57690
CHEMBL ID CHEMBL472850
  NP Activity Charts   Click to show/hide
  Activity Info  

 The Content Variation of Natural Product Induced by Different Factor(s)
      Species Name: Chaetomium globosum
  Factor Name: PDA medium [1]
              Species Info Factor Info
               Experiment Detail
The fungal strain C. globosum was separated from the sterilized leaves of G. biloba, a medicinal plant growing in Linyi, Shandong province, China. The fungus C. globosum was cultivated on PDA medium for 5 days at 28 ℃ to provide the culture broth (30 L).
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               Factor Part Location NP Content
 
PDA medium (28℃ + 5 days)
 Leaves Linyi, Shandong province, China
NP Content: 5.9 mg
      Species Name: Chaetomium globosum TY-2
  Factor Name: Oatmeal Medium [2]
              Species Info Factor Info
               Experiment Detail
A strain of C. globosum TY-2 was initially isolated from the plant Polygonatum sibiricum, collected in 2015 from Linan, Zhejiang Province, China. Serial transfers of one of the resulting colonies from Polygonatum sibiricum provided a pure strain of C. globosum. The fungal strain was cultured at 28 &#8451 for six weeks in a oatmeal medium (50 L) containing 1 % soluble sucrose and 0.1 % casein.
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               Factor Part Location NP Content
 
Oatmeal Medium with 1 % soluble sucrose and 0.1 % casein (28 degrees Celsius + 42Days)
 NA Linan, Zhejiang Province, China
NP Content: 3.6 mg
      Species Name: Penicillium sp. strain V11
  Factor Name: Rice medium [3]
              Species Info Factor Info
               Experiment Detail
The strain of Penicillium chrysogenum V11 was separated from the vein of Myoporum bontioides A. Gray in Leizhou Peninsula, China, in May 2014. The strain of Penicillium chrysogenum V11 was grown on an autoclaved rice medium (100 mL water, 100 g rice, 0.3 g crude sea salt each) in Erlenmeyer flasks (1 L × 100) at 28 ℃ and grown for 30 days under static conditions.
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               Factor Part Location NP Content
 
Rice medium (28℃ +30 days)
 Veins Leizhou Peninsula, China
NP Content: 120 mg
  Factor Name: Rice medium [4]
              Species Info Factor Info
               Experiment Detail
The strain of Penicillium chrysogenum V11 was isolated from the vein of Myoporum bontioides A. Gray in Leizhou Peninsula and deposited in the College of Materials and Energy, South China Agriculture University, Guangdong Province, China. The fungus was fermented with a rice medium (100 mL water, 100 g rice, 0.3 g crude sea salt) in Erlenmeyer flasks (1 L × 100) at 28 ℃ for 30 days under static conditions.
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               Factor Part Location NP Content
 
Rice medium (28℃ + 30 days)
 Veins Leizhou Peninsula, China
NP Content: 8 mg
References
1 Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
2 Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum
3 Penochalasin K, a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum V11 and its effective semi-synthesis
4 Bioactive Chaetoglobosins from the Mangrove Endophytic Fungus Penicillium chrysogenum