Fungal material and fermentation: The fungus Bulgaria inquinans (isolate MSp3-1) was isolated from a healthy sprout of mistletoe (Viscum album), collected in January 2017 at Julich, Germany. The fungus was cultivated on solid Czapek medium, which was prepared by autoclaving 200 mL of liquid Czapek medium with the addition of 5.0 g of bacto agar in a 1 L Erlenmeyer flask. The composition of liquid Czapek medium was 10.0 g dextrose, 20.0 g mannitol, 20.0 g maltose, 3.0 g yeast extract, 1.0 g corn steep liquor, 0.5 g tryptophan, 0.5 g K₂HPO₄.3H₂O, 0.3 g MgSO₄.7H₂O and 1 L of distilled water (pH value of the medium adjusted between 7.2-7.8). The fermentation was performed in 15 flasks at room temperature, under static conditions for 27 days. OSMAC experiments were carried out by growing the fungus on solid Czapek medium containing either 3.5 g NaCl, 3.5 g NaBr, 3.5 g NaI, 3.5 g NaNO₃, 3.5 g (NH₄)2SO₄ or mixtures of (a) MgSO₄.7H₂O, NaNO₃ and NaCl (2.5 g of each), (b) FeSO₄.7H₂O, NaNO₃ and NaCl (2.5 g of each), or (c) ZnSO₄.7H₂O, NaNO₃ and NaCl (2.5 g of each), added to each 1 L flask followed by extraction when the flasks were completely overgrown by the fungus. Based on the chromatographic profiles obtained from these experiments, a large-scale fermentation of B. inquinans was carried out by adding a mixture of MgSO₄.7H₂O, NaNO₃ and NaCl (2.5 g of each) to solid Czapek medium. The fungus was grown under static conditions for 33 days followed by extraction.

The fungus Phyllosticta capitalensis was isolated from the leaves of Loropetalum chinense var. rubrum, which collected from Nanjing, Jiangsu Province, P. R. China (31° 14′ N, 118° 22′ E), in August 2019. To prepare the seed culture, the strain was cultured on potato dextrose agar (PDA) at 28 &#8451 for 7 days. Agar plugs were cut into small pieces (approximately 0.5 × 0.5 × 0.5 cm³). Small pieces were added to ten Erlenmeyer flasks (250 mL) with 100 mL of potato dextrose liquid medium, and flasks were incubated on a rotary shaker at 28 &#8451 and 150 rpm for 5 days to prepare seed culture. Solid fermentation was carried out in 200 Erlenmeyer flasks (1 L) each containing 140 g of rice and 210 mL of distilled water with 5 mmol/L Nicotinamide, 0.1 mmol/L 5-aza-2-deoxycytidine, 0.25 mmol/L CuSO₄ 5H₂O, 0.5 g/L MgSO₄ and 0.5 g/L NaCl were sterilized at autoclave, and then, 10 mL of seed culture was added into each flask. All flasks were incubated at 28 &#8451 for 30 days.